TNF-a in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis

摘要

Nephrotoxic serum nephritis (NTN) produces severe kidney inflammation and injury, which is orchestrated by cells of the innate and adaptive immune systems (1). While NTN is widely used as a model of crescentic glomerulonephritis, renal pathology in NTN mice varies depending on the pathogenic antibody injected and can include glomerular cell proliferation and matrix deposition, tubular damage, and inflammatory cell infiltration. Later stages of NTN can manifest with interstitial fibrosis (29). While contributions of the immune system to glomerular pathology have been well documented, the role of inflammatory cells in the progression to tubulointerstitial fibrosis has received less scrutiny.