A Network of Coiled-Coil Associations Derived from Synthetic GCN4 Leucine-Zipper Arrays

摘要

The alpha-helical coiled coil was one of the first protein motifs whose structure was elucidated in detail.First described by Crick in 1953,the coiled coil is composed of at least two right-handed amphipathic a helices that wrap around each other into a left-handed supercoil such that their hydrophobic surfaces are in continuous contact(Figure 1a).