A 6-month systems toxicology inhalation study in ApoE ' mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke

摘要

Use of cigarettes is an established cause of clinical cardiovascular diseases (CVD) (79, 93, 114, 180, 183). Cigarette smoke (CS) is a complex chemical mixture containing more than 6,000 constituents (129). Excessive generation of harmful and potentially harmful constituents (HPHC) from combustion of tobacco and their inhalation have been identified as critical factors in the development of tobacco smoking-related diseases (14, 18, 63, 77, 84, 126, 136, 170, 178).