Beclin l/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho

摘要

Acute kidney injury (AKI) is a syndrome with sudden loss of renal function after exposure to renal insults. The failure to maintain homeostasis causes the accumulation of waste products (1, 9, 76) and damages remote organs such as the brain, heart, and lungs (26, 57). Patients with AKI have high short-term and long-term morbidity and mortality (1, 22, 44). Even when they survive and recover from AKI, the long-term outcome is far from benign, with substantial risk of progression to chronic kidney disease (CKD) and end-stage renal disease (6, 9, 21). The poor short-term and long-term outcomes are partially caused by lack of efficient and/or specific therapy.