Renal hemodynamics and fatty acid uptake: effects of obesity and weight loss

摘要

In both groups, regional blood perfusion was higher in the cortex than medulla; in either region, FFA uptake was -50% higher in the obese as a consequence of higher circulating FFA levels. Following weight loss (26 ± 8 kg), total renal blood How was reduced (P = 0.006). Renal volume, cGFR, cortical and medullary FFA uptake were decreased hut not fully normalized. Obesity is associated with renal structural, hemodynamic, and metabolic changes. Six months after bariatric surgery, the hemodynamic changes are reversed and the structural changes are improved. On the contrary, renal FFA uptake remains increased, driven by high substrate availability.