Developmental programming of sex-dependent alterations in lipid metabolism: A role for long-term, sex-specific alterations in LDL-receptor expression. Focus on 'Developmental programming of lipid metabolism and aortic vascular function in C57BL/6 mice: A novel study suggesting an involvement of LDL-receptor'

摘要

The nobel prize in physiology or medicine was awarded to Brown and Goldstein in 1985 for their discovery of the low-density lipoprotein (LDL) receptor and its importance in the regulation of cholesterol metabolism (2). Cholesterol, an essential component of the mammalian cell membrane, is transported within the circulation by a class of particles called lipoproteins. In humans, the most abundant cholesterol-containing lipoprotein, LDL, is removed from the blood primarily via hepatic LDL-receptor-mediated endocytosis