Chirality-Controlled Formation of P-Turn Secondary Structures in Short Peptide Chains:Gas-Phase Experiment versus Quantum Chemistry

摘要

Conformational preferences of short linear peptide chains,in particular the type of beta-turn they can adopt,were predicted early on by biochemists to be sensitive to the chirality of the backbone residues.Achiral or D-conformation residues are indeed found in natural molecules and used in peptido-mimetics,for drug-design purposes in particular,and they result in robust local-chain motifs.