Chemo-lmmunotherapy: Role of Indoleamine 2,3-Dioxygenase in Defining Immunogenic Versus Tolerogenic Cell Death in the Tumor Microenvironment

摘要

When established tumors are treated with chemotherapy many tumor cells die, and multiple tumor-associated antigens are released. It is becoming increasingly clear that tumors contain many immunogenic antigens [1, 2]; so, ideally, tumor cell death after chemotherapy should be an opportunity for immune activation [3-5],