Characteristics and Serotype Distribution of Childhood Cases of Invasive Pneumococcal Disease Following Pneumococcal Conjugate Vaccination in England and Wales, 2006–2014

摘要

We compared children with 7-valent (PCV7) and 13-valent (PCV13) pneumococcal conjugate vaccine failure in the UK. Vaccine failure was rare; those with PCV13 failure were more likely to be healthy and to develop lower respiratory tract infection with empyema.