Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda

Stein Catherine M.; Nsereko Mary; Malone LaShaunda L.; Okware Brenda; Kisingo Hussein; Nalukwago Sophie; Chervenak Keith; Mayanja-Kizza Harriet; Hawn Thomas R.; Boom W. Henry

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Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda

机译：乌干达坎帕拉高度暴露的结核病患者抗潜在结核分枝杆菌感染的长期稳定性

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Background. Resistance to latent Mycobacterium tuberculosis (M. tb) infection, identified by persistently negative tuberculin skin tests (TST) and interferon-gamma release assays (IGRA), after close contact with pulmonary tuberculosis (TB) patients has not been extensively characterized. Stability of this "resistance" beyond 2 years from exposure is unknown.

机译：背景。抗潜在的结核分枝杆菌（M.TB）感染，通过持续阴性结核蛋白皮肤试验（TST）和干扰素 - γ释放测定（IGRA）在与肺结核（TB）紧密接触后尚未进行广泛的表征。距离暴露的2年之后这种“阻力”的稳定性是未知的。

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来源
《Clinical infectious diseases 》 |2019年第10期| 共8页
作者
Stein Catherine M.; Nsereko Mary; Malone LaShaunda L.; Okware Brenda; Kisingo Hussein; Nalukwago Sophie; Chervenak Keith; Mayanja-Kizza Harriet; Hawn Thomas R.; Boom W. Henry;
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作者单位

Case Western Reserve Univ Sch Med Dept Populat &

Quantitat Hlth Sci Cleveland OH USA;

Uganda CWRU Res Collaborat Kampala Uganda;

Case Western Reserve Univ Sch Med TB Res Unit Cleveland OH USA;

Uganda CWRU Res Collaborat Kampala Uganda;

Uganda CWRU Res Collaborat Kampala Uganda;

Uganda CWRU Res Collaborat Kampala Uganda;

Case Western Reserve Univ Sch Med TB Res Unit Cleveland OH USA;

Makerere Univ Sch Med Dept Med Kampala Uganda;

Univ Washington Dept Med Seattle WA USA;

Case Western Reserve Univ Sch Med TB Res Unit Cleveland OH USA;

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原文格式 PDF
正文语种 eng
中图分类传染病 ;
关键词
TB exposure; case-contact study; resistance to infection; TB outcomes;

机译：结核病曝光;案例接触研究;抗感染;结论结果;

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专利

1. Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda [J] . Stein Catherine M., Nsereko Mary, Malone LaShaunda L., Clinical infectious diseases . 2019 ,第10期

机译：乌干达坎帕拉高度暴露的结核病患者抗潜在结核分枝杆菌感染的长期稳定性
2. Immune correlates of acute Mycobacterium tuberculosis infection in household contacts in Kampala, Uganda. [J] . Whalen CC, Chiunda A, Zalwango S, The American Journal of Tropical Medicine and Hygiene . 2006 ,第1期

机译：乌干达坎帕拉家庭接触者的急性结核分枝杆菌感染的免疫相关性。
3. Innate and adaptive immune responses during acute M. tuberculosis infection in adult household contacts in Kampala, Uganda [J] . MahanC.S., ZalwangoS., ThielB.A., The American Journal of Tropical Medicine and Hygiene . 2012 ,第4期

机译：乌干达坎帕拉成人家庭接触者急性结核分枝杆菌感染期间的先天性和适应性免疫反应
4. Mycobacterium tuberculosis Antigen-Specific IL-2R and IP-10 Expression Changes in Chronic Obstructive Pulmonary Disease Patients with in Latent Tuberculosis Infection [C] . Sungyong Bong, Sunghyun Kim, Joo Hwan Hwang, International Molecular Medicine Tri-Conference. . 2016

机译：结核分枝杆菌抗原特异性IL-2R和IP-10表达变化慢性阻塞性肺病患者潜在结核病感染
5. An analysis of factors mediating the transmission and development of active tuberculosis in pediatric household contacts of sputum smear positive tuberculosis cases in Kampala, Uganda. [D] . Mandalakas, Anna Maria. 2000

机译：乌干达坎帕拉痰涂片阳性结核病小儿家庭接触者介导活动性结核病传播和发展的因素分析。
6. Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala Uganda [O] . Catherine M Stein, Mary Nsereko, LaShaunda L Malone, -1

机译：乌干达坎帕拉高暴露度结核病家庭接触者对潜在的结核分枝杆菌感染的抵抗力的长期稳定性。
7. Faculty Opinions recommendation of Resistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Uganda. [O] . Padmini Salgame, Vaishnavi Kaipilyawar 2019

机译：教师观点建议乌干达坎帕拉结核病患有结核病感染和疾病的抗性和易感性。

Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda

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