Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials

Borges Alvaro H.; Lundh Andreas; Tendal Britta; Bartlett John A.; Clumeck Nathan; Costagliola Dominique; Daar Eric S.; Echeverria Patricia; Gisslen Magnus; Huedo-Medina Tania B.; Hughes Michael D.; Hullsiek Katherine Huppler; Khabo Paul; Komati Stephanus; Kumar Princy; Lockman Shahin; MacArthur Rodger D.; Maggiolo Franco; Matteelli Alberto; Miro Jose M.; Oka Shinichi; Petoumenos Kathy; Puls Rebekah L.; Riddler Sharon A.; Sax Paul E.; Sierra-Madero Juan; Torti Carlo; Lundgren Jens D.

首页> 外文期刊>Clinical infectious diseases >Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials

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Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials

机译：壬核苷逆转录酶抑制剂与蓖麻油血清患者的初步治疗艾滋病毒感染的初步治疗方案：随机试验的系统审查和细胞分析

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Background. Previous studies suggest that nonnucleoside reverse-transcriptase inhibitors (NNRTIs) cause faster virologic suppression, while ritonavir-boosted protease inhibitors (PI/r) recover more CD4 cells. However, individual trials have not been powered to compare clinical outcomes.

机译：背景。以前的研究表明，壬核苷逆转录酶抑制剂（NNRTIS）引起更快的病毒学抑制，而Ritonavir - 增强蛋白酶抑制剂（PI / R）恢复更多CD4细胞。但是，个别试验尚未得到动力比较临床结果。

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来源
《Clinical infectious diseases 》 |2016年第2期| 共13页
作者
Borges Alvaro H.; Lundh Andreas; Tendal Britta; Bartlett John A.; Clumeck Nathan; Costagliola Dominique; Daar Eric S.; Echeverria Patricia; Gisslen Magnus; Huedo-Medina Tania B.; Hughes Michael D.; Hullsiek Katherine Huppler; Khabo Paul; Komati Stephanus; Kumar Princy; Lockman Shahin; MacArthur Rodger D.; Maggiolo Franco; Matteelli Alberto; Miro Jose M.; Oka Shinichi; Petoumenos Kathy; Puls Rebekah L.; Riddler Sharon A.; Sax Paul E.; Sierra-Madero Juan; Torti Carlo; Lundgren Jens D.;
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作者单位

Univ Copenhagen Rigshosp Dept Infect Dis Ctr Hlth &

Infect Dis Res Roskilde Denmark;

Zealand Univ Hosp Dept Internal Med Roskilde Denmark;

Danish Hlth Author Copenhagen Denmark;

Kilimanjaro Christian Med Ctr Moshi Tanzania;

St Pierre Univ Hosp Dept Infect Dis Brussels Belgium;

INSERM Inst Pierre Louis Epidemiol &

Sante Publ Paris France;

Harbor UCLA Med Ctr Los Angeles Biomed Res Inst Dept Med Torrance CA 90509 USA;

Autonomous Univ Barcelona Germans Trias &

Pujol Univ Hosp Dept HIV Lluita Sida Fdn E-08193;

Univ Gothenburg Sahlgrenska Acad Dept Infect Dis Gothenburg Sweden;

Univ Connecticut Dept Allied Hlth Sci Hartford CT 06112 USA;

Harvard Sch Publ Hlth Dept Biostat Boston MA USA;

Univ Minnesota Sch Publ Hlth Div Biostat Minneapolis MN 55455 USA;

Project Phidisa Pretoria South Africa;

Project Phidisa Pretoria South Africa;

Georgetown Univ Hosp Washington DC USA;

Harvard Sch Publ Hlth Dept Immunol &

Infect Dis Boston MA USA;

Newland Immunol Ctr Excellence Southfield MI USA;

Osped Riuniti Bergamo Div Malattie Infett Bergamo Italy;

Univ Brescia Inst Infect &

Trop Dis I-25121 Brescia Italy;

Univ Barcelona Hosp Clin IDIBAPS Infect Dis Serv E-08007 Barcelona Spain;

Natl Ctr Global Hlth &

Med AIDS Clin Ctr Tokyo Japan;

UNSW Australia Kirby Inst Sydney NSW Australia;

UNSW Australia Kirby Inst Sydney NSW Australia;

Univ Pittsburgh Dept Med Pittsburgh PA 15260 USA;

Harvard Med Sch Brigham &

Womens Hosp Div Infect Dis Boston MA USA;

Inst Nacl Ciencias Med &

Nutr Salvador Zubiran Mexico City DF Mexico;

Magna Graecia Univ Catanzaro Dept Med &

Surg Sci Univ Unit Infect Dis Catanzaro Italy;

Univ Copenhagen Rigshosp Dept Infect Dis Ctr Hlth &

Infect Dis Res Roskilde Denmark;

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原文格式 PDF
正文语种 eng
中图分类传染病 ;
关键词
HIV; antiretroviral therapy; protease inhibitor; nonnucleoside reverse transcriptase inhibitor; metaanalysis;

机译：艾滋病毒;抗逆转录病毒治疗;蛋白酶抑制剂;壬核苷逆转录酶抑制剂;metaanysis;

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1. Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials [J] . Borges Alvaro H., Lundh Andreas, Tendal Britta, Clinical infectious diseases . 2016 ,第2期

机译：基于Nonnucleoside逆转录酶抑制剂相对于利托那韦增强蛋白酶抑制剂的HIV感染初始治疗方案：系统评价和随机试验的荟萃分析
2. Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials [J] . Borges Alvaro H., Lundh Andreas, Tendal Britta, Clinical infectious diseases . 2016 ,第2期

机译：壬核苷逆转录酶抑制剂与蓖麻油血清患者的初步治疗艾滋病毒感染的初步治疗方案：随机试验的系统审查和细胞分析
3. Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment. [J] . Haubrich RH, Riddler SA, DiRienzo AG, AIDS . 2009 ,第9期

机译：一项针对初始HIV治疗的核苷，非核苷和蛋白酶抑制剂保留方案的随机试验的代谢结果。
4. A systematic review of randomized controlled trials for prevention or treatment of atopic dermatitis in dogs: 2008-2011 update [C] . Thierry Olivry, Petra Bizikova World Congress of Veterinary Dermatology . 2013

机译：对狗的预防或治疗特应性皮炎的随机对照试验进行系统综述：2008-2011更新
5. Methods for Exploring Heterogeneity in Systematic Reviews of Randomized Controlled Trials. [D] . Gagnier, Joel J. 2010

机译：在随机对照试验的系统评价中探索异质性的方法。
6. Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted ProteaseInhibitor–based Regimens for Initial Treatment of HIV Infection: A Systematic Review andMetaanalysis of Randomized Trials [O] . Álvaro H. Borges, Andreas Lundh, Britta Tendal, -1

机译：Nonnucleoside逆转录酶抑制剂vs Ritonavir增强蛋白酶基于抑制剂的HIV感染初始治疗方案：系统评价和随机试验的荟萃分析
7. Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment [O] . Richard H Haubrich, Sharon A Riddler, A Gregory DiRienzo, 2009

机译：用于初始艾滋病毒治疗的核苷，壬核苷和蛋白酶抑制剂备件方案的随机试验中的代谢结果

Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor-based Regimens for Initial Treatment of HIV Infection: A Systematic Review and Metaanalysis of Randomized Trials

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