Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus A Mendelian Randomization Analysis

Dale Caroline E.; Fatemifar Ghazaleh; Palmer Tom M.; White Jon; Prieto-Merino David; Zabaneh Delilah; Engmann Jorgen E. L.; Shah Tina; Wong Andrew; Warren Helen R.; McLachlan Stela; Trompet Stella; Moldovan Max; Morris Richard W.; Sofat Reecha; Kumari Meena; Hypponen Elina; Jefferis Barbara J.; Gaunt Tom R.; Ben-Shlomo Yoav; Zhou Ang; Gentry-Maharaj Aleksandra; Ryan Andy; de Mutsert Renee; Noordam Raymond; Caulfield Mark J.; Jukema J. Wouter; Worrall Bradford B.; Munroe Patricia B.; Menon Usha; Power Chris; Kuh Diana; Lawlor Debbie A.; Humphries Steve E.; Mook-Kanamori Dennis O.; Sattar Naveed; Kivimaki Mika; Price Jacqueline F.; Smith George Davey; Dudbridge Frank; Hingorani Aroon D.; Holmes Michael V.; Casas Juan P.

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Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus A Mendelian Randomization Analysis

机译：患有冠心病，中风亚型和2型糖尿病的脂肪性和体脂分布的因果关系

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摘要

BACKGROUND: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations of central adiposity (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) and general adiposity (body mass index [BMI]) with cardiometabolic disease.

机译：背景：不同肥胖措施对心血管疾病病因的影响仍不清楚。在本文中，我们量化和对比中央肥胖的因果关系（对体重指数[WHRADJBMI]调整的腰部与髋关节比率[WHRADJBMI]）和具有心肌疾病的一般肥胖（体重指数[BMI]）。

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来源
《Circulation: An Official Journal of the American Heart Association》 |2017年第24期|共36页
作者
Dale Caroline E.; Fatemifar Ghazaleh; Palmer Tom M.; White Jon; Prieto-Merino David; Zabaneh Delilah; Engmann Jorgen E. L.; Shah Tina; Wong Andrew; Warren Helen R.; McLachlan Stela; Trompet Stella; Moldovan Max; Morris Richard W.; Sofat Reecha; Kumari Meena; Hypponen Elina; Jefferis Barbara J.; Gaunt Tom R.; Ben-Shlomo Yoav; Zhou Ang; Gentry-Maharaj Aleksandra; Ryan Andy; de Mutsert Renee; Noordam Raymond; Caulfield Mark J.; Jukema J. Wouter; Worrall Bradford B.; Munroe Patricia B.; Menon Usha; Power Chris; Kuh Diana; Lawlor Debbie A.; Humphries Steve E.; Mook-Kanamori Dennis O.; Sattar Naveed; Kivimaki Mika; Price Jacqueline F.; Smith George Davey; Dudbridge Frank; Hingorani Aroon D.; Holmes Michael V.; Casas Juan P.;
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作者单位

UCL UCL Inst Hlth Informat Farr Inst Hlth Informat Res 222 Euston Rd London NW1 2DA England;

UCL UCL Inst Hlth Informat Farr Inst Hlth Informat Res 222 Euston Rd London NW1 2DA England;

Univ Lancaster Dept Math &

Stat Lancaster England;

UCL UCLGenet Inst London England;

UCL UCL Inst Hlth Informat Farr Inst Hlth Informat Res 222 Euston Rd London NW1 2DA England;

Kings Coll London Social Genet &

Dev Psychiat London England;

UCL Inst Cardiovasc Sci London England;

UCL Inst Cardiovasc Sci London England;

UCL MRC Unit Lifelong Hlth &

Ageing London England;

Queen Mary Univ London Barts &

London Sch Med &

Dent William Harvey Res Inst Clin Pharmacol;

Univ Edinburgh Usher Inst Populat Hlth Sci &

Informat Edinburgh Midlothian Scotland;

Leiden Univ Med Ctr Dept Cardiol Leiden Netherlands;

S Australian Hlth &

Med Res Inst Adelaide SA Australia;

Univ Bristol Sch Social &

Community Med Bristol Avon England;

UCL Ctr Clin Pharmacol London England;

Univ Essex Inst Social &

Econ Res Colchester Essex England;

S Australian Hlth &

Med Res Inst Adelaide SA Australia;

UCL Dept Primary Care &

Populat Hlth Royal Free Campus London England;

Univ Bristol Sch Social &

Community Med Bristol Avon England;

Univ Bristol Sch Social &

Community Med Bristol Avon England;

Univ South Australia Sch Hlth Sci Adelaide SA Australia;

UCL Inst Womens Hlth Dept Womens Canc London England;

UCL Inst Womens Hlth Dept Womens Canc London England;

Leiden Univ Med Ctr Dept Clin Epidemiol Leiden Netherlands;

Leiden Univ Med Ctr Sect Gerontol &

Geriatr Dept Internal Med Leiden Netherlands;

Queen Mary Univ London Barts &

London Sch Med &

Dent William Harvey Res Inst Clin Pharmacol;

Leiden Univ Med Ctr Dept Cardiol Leiden Netherlands;

Univ Virginia Dept Neurol Charlottesville VA USA;

Queen Mary Univ London Barts &

London Sch Med &

Dent William Harvey Res Inst Clin Pharmacol;

UCL Inst Womens Hlth Dept Womens Canc London England;

Inst Child Hlth Populat Policy &

Practice UCL Great Ormond St London England;

UCL MRC Unit Lifelong Hlth &

Ageing London England;

Univ Bristol Sch Social &

Community Med Bristol Avon England;

UCL Inst Cardiovasc Sci London England;

Leiden Univ Med Ctr Dept Clin Epidemiol Leiden Netherlands;

BHF Glasgow Cardiovasc Res Ctr Fac Med Glasgow Lanark Scotland;

UCL Dept Epidemiol &

Publ Hlth London England;

Univ Edinburgh Usher Inst Populat Hlth Sci &

Informat Edinburgh Midlothian Scotland;

Univ Bristol Sch Social &

Community Med Bristol Avon England;

London Sch Hyg &

Trop Med Dept Noncommunicable Dis Epidemiol London England;

UCL UCL Inst Hlth Informat Farr Inst Hlth Informat Res 222 Euston Rd London NW1 2DA England;

Univ Oxford Nuffield Dept Populat Hlth Clin Trial Serv Unit Big Data Inst Bldg Oxford England;

UCL UCL Inst Hlth Informat Farr Inst Hlth Informat Res 222 Euston Rd London NW1 2DA England;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
adiposity; body fat distribution; body mass index; coronary artery disease; Mendelian randomization analysis; stroke; waist-hip ratio;

机译：肥胖;体脂分布;体重指数;冠状动脉疾病;孟德利安随机化分析;中风;腰臀比;

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专利

1. Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus A Mendelian Randomization Analysis [J] . Dale Caroline E., Fatemifar Ghazaleh, Palmer Tom M., Circulation: An Official Journal of the American Heart Association . 2017,第24期

机译：患有冠心病，中风亚型和2型糖尿病的脂肪性和体脂分布的因果关系
2. Association of Educational Attainment With Adiposity, Type 2 Diabetes, and Coronary Artery Diseases: A Mendelian Randomization Study [J] . Cao Min, Cui Bin Frontiers in Public Health . 2020,第2期

机译：肥胖，2型糖尿病和冠状动脉疾病的教育成就协会：孟德尔随机化研究
3. Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis [J] . Liu Junfeng, Rutten-Jacobs Loes, Liu Ming, Stroke: A Journal of Cerebral Circulation . 2018,第6期

机译：2型糖尿病患者对脑小血管疾病的因果影响：孟德利安随机化分析
4. Relationship between Serum Lipid Index, C Reaction Protein (CRP), Insulin Resistance and Coronary Artery Disease in Diabetes Mellitus Patients Complicated with Coronary Atherosclerotic Heart Disease (CAHD) and Correlation Analysis [C] . Hui Li, Zhanhua Li, Fanjin Zeng, International Conference on Education, Social Science, Management and Sports . 2017

机译：糖尿病患者糖尿病患者血清脂指数，C反应蛋白（CRP），胰岛素抵抗和冠状动脉疾病的关系及冠状动脉粥样硬化（CAHD）和相关分析
5. Arsenic exposure in drinking water and the associated risk with coronary heart disease and type II diabetes mellitus. [D] . James, Katherine. 2010

机译：饮用水中砷的暴露以及与冠心病和II型糖尿病相关的风险。
6. Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis [O] . Caroline E. Dale, Ghazaleh Fatemifar, Tom M. Palmer, -1

机译：肥胖和体脂分布与冠心病中风亚型和2型糖尿病的因果关系：孟德尔随机分析
7. Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus:A Mendelian Randomization Analysis [O] . Dale, Caroline E, Fatemifar, Ghazaleh, Palmer, Tom M, 2017

机译：肥胖和体脂分布与冠心病，中风亚型和2型糖尿病的因果关系：孟德尔随机分析

Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus A Mendelian Randomization Analysis

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