Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers? A Double-blind, Randomized, Crossover Trial

摘要

Background: Although opioids in general and remifentanil in particular have been shown to induce hyperalgesia, data regarding fentanyl are scarce. Thus, the authors investigated the effect of fentanyl dosing on pain perception and central sensitization in healthy volunteers using established pain models.