A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs

Davidson Elyad M.; Haroutounian Simon; Kagan Leonid; Naveh Michael; Aharon Arnon; Ginosar Yehuda

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A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs

机译：新型前脂质体罗哌卡因油：猪皮下给药后的药代动力学-药效学研究

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BACKGROUND: Liposomal local anesthetics are limited by a short liposomal shelf-life, even when under refrigeration. We describe a novel proliposomal ropivacaine that produces liposomes in situ, only after exposure to aqueous media.

机译：背景：脂质体局部麻醉药即使在冷藏下也受脂质体保质期短的限制。我们描述了一种新型的脂质体罗哌卡因，仅在暴露于水性介质后才可原位产生脂质体。

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《Anesthesia and Analgesia: Journal of the International Anesthesia Research Society》 |2016年第5期|共10页
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Davidson Elyad M.; Haroutounian Simon; Kagan Leonid; Naveh Michael; Aharon Arnon; Ginosar Yehuda;
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正文语种 eng
中图分类麻醉学;
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1. A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs [J] . Davidson Elyad M., Haroutounian Simon, Kagan Leonid, Anesthesia and Analgesia: Journal of the International Anesthesia Research Society . 2016,第5期

机译：新型前脂质体罗哌卡因油：猪皮下给药后的药代动力学-药效学研究
2. Determination of the disappearance rate of iodine-125 labelled oils from the injection site after intramuscular and subcutaneous administration to pigs. [J] . Larsen SW, Rinvar E, Svendsen O, International Journal of Pharmaceutics . 2001,第1a2期

机译：猪肌肉内和皮下给药后，注射部位碘125标记油的消失率的测定。
3. Subcutaneous Administration of Carbidopa Enhances Oral Levodopa Pharmacokinetics: A Series of Studies Conducted in Pigs, Mice, and Healthy Volunteers [J] . Ronit Shaltiel-Karyo, Yoseph Caraco, Eduardo Zawaznik, Clinical neuropharmacology . 2019,第4期

机译：皮下给药碳化碳增强口服左旋多巴药代动力学：在猪，小鼠和健康志愿者中进行的一系列研究
4. Pharmacokinetic-Pharmacodynamic Study of Subcutaneous Injection of Nandrolone Decanoate Using Dried Blood Spots (DBS) Blood Sampling coupled with LC-MS/MS [C] . Gurmeet Kaur Surindar Singh, Leo Turner, Reena Desai, International Mass Spectrometry Conference . 2014

机译：用干血斑（DBS）耦合LC-MS / MS的血液取样皮下注射Nandrolone癸酸的药代动力学 - 药物动力学研究
5. Evaluation of the pharmacokinetic-pharmacodynamic relationship, metabolism and plasma protein binding of the novel antitumor agent, 2-methoxyestradiol (2ME2), following oral administration in patients with solid tumors. [D] . Lakhani, Nehal Jagdish. 2005

机译：实体瘤患者口服后评估新型抗肿瘤药2-甲氧基雌二醇（2ME2）的药代动力学与药效关系，代谢和血浆蛋白结合。
6. Elongation of oestrous cycle in the guinea-pig following subcutaneous or intra-uterine administration of indomethacin [O] . E. W. Horton, N. L. Poyser 1973

机译：吲哚美辛的皮下或子宫内给药后豚鼠的发情周期延长
7. Influence of estradiol administration on estrogen receptors of nasal mucosa: an experimental study on guinea pigs✩✩Please cite this article as: Costa HO, Castro-Neto NP, Rossi LM, Millas I, Coelho F, Silva L. Influence of estradiol administration on estrogen receptors of nasal mucosa: an experimental study on guinea pigs. Braz J Otorhinolaryngol. 2014; 80:18-23. [O] . Olival Costa Henrique, de Castro Neto Ney Penteado, Mara Rossi Lia, 2014

机译：雌二醇对鼻粘膜雌激素受体的影响：豚鼠的实验研究✩✩请引用本文：何浩然，卡斯特罗-内托·NP，罗西·LM，米拉斯一世，科埃略·F，席尔瓦·L。鼻粘膜的雌激素受体：豚鼠的实验研究。布拉兹·J·耳鼻咽喉科杂志。 2014; 80：18-23。
8. Repeated Dose Toxicity Studies Including Plasma Levels on Nsc 109229 Following Daily I. V. Administration to Monkeys and Dogs. Range Finding Toxicity Studies in Mice Following Single I. V. Administration and Antigenic Studies in Guinea Pigs and Rabbits [R] . Rakieten, N., Schein, P. S., Davis, R. D. 1968

机译：重复剂量毒性研究包括每日I.V.给猴子和狗施用Nsc 109229的血浆水平。在单一I.V.豚鼠和家兔的给药和抗原研究中对小鼠的范围寻找毒性研究

A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs

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