Potential applications of multifunctional mesoporous carbon nanoplatform for tumor microenvironment improving by combined chemo-/phototherapy

摘要

At present, conventional drug therapy for tumor strongly stimulates tumor tissue, leading to tumor necrosis and acute inflammatory response, and tumor metastasis. How to kill tumor cells under mild conditions and prolong the survival of patients is a hot topic of tumor therapy. In this study, a multifunctional nanoplatform was designed based on mesoporous carbon nanoparticles, grafting with anti-inflammatory drug (celecoxib) and loading chemotherapy drug (doxorubicin). The constructed nanoplatform mesoporous carbon/celecoxib @doxorubicin was found to capable of, induce intravascular thrombosis, blocking nutrient supply for tumor, and over-inflammatory suppression avoiding acute tissue necrosis. Meanwhile, this study demonstrates combined chemo- and photothermal therapy and exhibits a promising potential in cancer therapy. (C) 2020 Elsevier Ltd. All rights reserved.