Gum tragacanth stabilized green gold nanoparticles as cargos for Naringin loading: A morphological investigation through AFM

摘要

Highlights ? Gum tragacanth stabilized green AuNPs were synthesized. ? The fabricated AuNPs loaded increased concentration of Naringin. ? Naringin revealed enhanced bactericidal potential after loading in AuNPs. ? Naringin loaded in AuNPs exerted greater degradation effects on bacterial morphologies. Abstract Gold nanoparticles (AuNPs) have attracted greater scientific interests for the construction of drugs loading cargos due to their biocompatibility, safety and facile surface modifications. This study deals with the fabrication of gum tragacanth (GT) green AuNPs as carrier for Naringin, a less water soluble therapeutic molecule. The optimized AuNPs were characterized through UV–vis spectroscopy, FT-IR and atomic force microscope (AFM). Naringin loaded nanoparticles were investigated for their bactericidal potentials using Tetrazolium Microplate assay. Morphological studies conducted via AFM revealed spherical shape for AuNPs with nano-range size and stabilized by GT multi-functional groups. The AuNPs acted as carrier for increased amount of Naringin. Upon loading in AuNPs, Naringin An increased in the bactericidal potentials of Naringin was observed after loading on AuNPs against various tested bacterial strains. This was further authenticated by the surface morphological analysis, showing enhanced membrane destabilizing effects of loaded Naringin. The results suggest that GT stabilized green AuNPs can act as effective delivery vehicles for enhancing bactericidal potentials of Naringin. ]]>