Structures, physico-chemical properties, production and (potential) applications of sucrose-derived alpha-D-glucans synthesized by glucansucrases

摘要

Glycoside hydrolase family 70 (GH70) glucansucrases produce alpha-D-glucan polysaccharides (e.g. dextran), which have different linkage composition, branching degree and size distribution, and hold potential applications in food, cosmetic and medicine industry. In addition, GH70 branching sucrases add single alpha-(1 -> 2) or alpha-(1 -> 3) branches onto dextran, resulting in highly branched polysaccharides with "comb-like" structure. The physico-chemical properties of these alpha-D-glucans are highly influenced by their linkage compositions, branching degrees and sizes. Among these alpha-D-glucans, dextran is commercially applied as plasma expander and separation matrix based on extensive studies of its structure and physico-chemical properties. However, such detailed information is lacking for the other type of alpha-D-glucans. Aiming to stimulate the application of alpha-D-glucans produced by glucansucrases, we present an overview of the structures, production, physico-chemical properties and (potential) applications of these sucrose-derived alpha-D-glucan polysaccharides. We also discuss bottlenecks and future perspectives for the application of these alpha-D-glucan polysaccharides.