Size-effect of gold nanorods on modulating the kinetic process of amyloid-beta aggregation

摘要

Inhibiting the A beta aggregation and understanding the kinetic process of A beta fibrillation are very important for exploring possible tactics to treat AD. Here size-effect of Au NRs are reported to modulate the process of A beta fibrillation. The results indicate that CTAB-stabilized Au NRs could efficiently suppress A beta fibrillation and the inhibition efficiency of larger Au NRs is better. We calculated the relationship between A beta aggregation rates and the sizes of Au NRs and found that the rate constant k was a quadratic function of diameters or lengths. This work provides a new strategy for exploring size-effect of nanoparticles on A beta fibrillation.