The effects of hydroxyethyl starch on cultured renal epithelial cells.

摘要

The use of hydroxyethyl starch (HES) as a plasma expander in the critically ill is highly controversial. The controversy is also driven by claims that HES has properties beyond plasma expansion that are held to be beneficial in patients with sepsis, in particular, antiinflammatory properties or effects on microcirculation and oxygenation. The number of experimental studies supporting these claims and published by proponents of HES is growing rapidly, despite the fact that we have learned in recent years that these mechanisms are incredibly complex, and the course of sepsis is not reflected, let alone influenced, by the modulation of 1 or 2 single molecules.