Effect of Channel Geometry on Ionic Current Signal of a Bridge Circuit Based Microfluidic Channel

摘要

Bridge circuit based ionic current sensing in a microfluidic channel has attracted attention as a highly sensitive analytical method for bio-related molecules and particles. However, channel geometry which greatly influences the detected ionic current has not been investigated. Here, we investigate experimentally and theoretically the effect of differences in the microfluidic channel geometry on shapes and amplitude of signals in ionic current sensing. Our results clarify the geometrical effect of the channel in the bridge circuit based ionic current sensing method.