Perioperative statin therapy may be implicated in a wide array of drug-drug interactions.

摘要

To the Editor:-We read with interest and appreciation the excellent article by Le Manach et al. in the June 2008 issue of Anesthesiology entitled "Statin Therapy within the Perioperative Period: Clinical Concepts and Commentary." However, there is an important area, namely drug-drug interactions involving statins, which merits more attention than the brief treatment in that review. We would like to make readers aware that a wide array of interactions can occur in the perioperative period and have been responsible for considerable morbidities.