PEG/SBA-15-containing acrylic bone cement with enhanced drug release

摘要

PMMA-based bone cements Formulated with PEG/SBA-15 were synthesized to achieve efficient and sustainable release of drugs. The presence of PEG/SBA-15 has a beneficial effect on the release of gentamicin (GTMC) in 70 days. The release of GTMC was improved markedly when the mass ratio of PEG/SBA-15 was up to 30% without notable change in mechanical properties. As a comparison, limited improvement of the GTMC release was found in the bone cement formulated with SBA-15 or PEG alone, while high content of single SBA-15 shown detrimental effect on the mechanical properties although the release of GTMC could be increased, disclosing the synergism of PEG and SBA-15. A normalized drug release model was adopted to describe the drug-release kinetics in the materials, and the diffusion coefficients were obtained. The excellent antimicrobial properties and low cytotoxicity of the materials have also been confirmed, demonstrating the potential applicability of the material in orthopedic surgery. (C) 2019 Published by Elsevier Ltd.