Synthesis of a novel nanostructured zinc oxide/baghdadite coating on Mg alloy for biomedical application: In-vitro degradation behavior and antibacterial activities

摘要

In this research, zinc oxide (ZnO) and zinc oxide/baghdadite (ZnO/Ca3ZrSi2O9) were prepared on the surface of Mg alloy using physical vapor deposition (PVD) coupled with electrophoretic deposition (EPD). For this purpose, the nanostructured ZnO was prepared with a thickness of 900 nm and crystallite sizes of 64 nm as under layer while nanostructured baghdadite with a thickness of 10 gm was deposited on the Mg alloy substrate as an over-layer. Electrochemical measurement exhibited that the ZnO/Ca3ZrSi2O9-coated specimen has a higher corrosion resistance and superior stability in simulated body fluid (SBF) solution in comparison with the ZnO-coated and bare Mg alloy samples. Antibacterial activities of the uncoated and coated specimens were evaluated against various pathogenic species (Escherichia coli, Klebsiella pneumoniae, and Shigella dysenteriae) via disc diffusion method. The obtained results showed that ZnO and ZnO/Ca3ZrSi2O9 coatings have great zones of inhibition (ZOI) against E. coli, Klebsiella, and Shigella. However, less ZOI was found around the bare Mg alloy. Therefore, ZnO/Ca3ZrSi2O9 is a promising coating for orthopedic applications of biodegradable Mg alloys considering its excellent antibacterial activities and high corrosion resistance.