Influence of sodium alginate and methylcellulose on hydrolysis and physicochemical properties of alpha-TCP based materials

摘要

The effect of the sodium alginate and methylcellulose modifiers on hydrolysis, setting reaction, microstructure, mechanical and in vitro properties of alpha-TCP based materials was investigated. It was found that the presence of sodium alginate impeded alpha-TCP hydrolysis to hydroxyapatite, which may have a significant influence on resorbability, biodegradation and biological behavior of biomaterials. There were several reasons for these phenomena, such as: (I) the gelation of sodium alginate in the presence of Ca2+, (II) the creation of an organic layer which impedes the diffusion of water molecules to alpha-TCP and (III) the uptake of water molecules by sodium alginate. The inhibitory effect was not observed for methylcellulose and it was diminished in simulated body fluid. Additionally, it was demonstrated that the examined cements varied in their microstructure, setting times and compressive strengths, depending on the applied kind of a polymer additive. The cement containing sodium alginate had a higher compressive strength (20 +/- 8 MPa) than the one with methylcellulose (17 +/- 4 MPa) and the one lacking polymer (14 +/- 4 MPa). All the developed materials exhibited high bioactivity in vitro.