Safety of modern starches used during surgery: Misleading conclusions

摘要

The recent review by Van Der Linden et al. concludes "that data in the peer reviewed literature do not suggest an adverse safety signal" when tetrastarch is used perioperatively. The review as acknowledged by the authors was commissioned by a tetrastarch manufacturer. However, the unfortunate timing of publication immediately after publication of the Crystalloid Versus Hydroxyethyl Starch Trial may lead readers to underestimate safety concerns related to use of hydroxyethyl starches (HESs) in surgical patients. Major trials purely in the surgical setting are still lacking