Combination of p16(INK4a)/Ki67 Immunocytology and HPV Polymerase Chain Reaction for the Noninvasive Analysis of HPV Involvement in Head and Neck Cancer

摘要

BACKGROUNDHigh-risk human papillomavirus (HPV) infection has been identified as a relevant risk for the development of head and neck squamous cell carcinomas (HNSCCs). As HPV status has also gained a role as a prognostic and predictive biomarker for this entity, there is a growing demand for valid HPV testing in HNSCC patients