An 18-year retrospective study on the outcomes of keratoacanthomas with different treatment modalities at a single academic centre

摘要

Dear Editors, The clinical course for keratoacanthomas (KAs) varies from self-resolving to invasive cancers.1'2 KA is often treated with surgical intervention," but other treatments such as electrodessication and curettage,4 cryotherapy,4 topical medications,2'5 intralesional chemotherapy,2 acitretin2 and active surveillance have been employed. Randomized controlled studies of different treatment modalities are lacking. The largest systematic review consisted of 113 case reports and case series (445 patients included) and reported 18 recurrent or persistent KA cases (4%),2 but this data is prone to publication bias, as unusual cases are more likely to be reported and treatment outcomes could not be directly compared.