Chronic sun exposure is associated with distinct histone acetylation changes in human skin

摘要

Background Photoageing is attributed to continuous sunlight or artificial ultraviolet exposure and manifests as clinical and histological changes in skin. Epigenetic changes have been found to be involved in the pathogenesis of photoageing. However, the underlying mechanisms are unclear. Objectives To analyse histone modification patterns in sun exposed and nonexposed skin, and to identify the abnormally histone-modified genes related to photoageing.