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首页> 外文期刊>Bulletin of experimental biology and medicine >Expression of mitochondrial uncoupling protein UCP2 in the brain of rats after hippocampal injury inflicted by kainic acid.
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Expression of mitochondrial uncoupling protein UCP2 in the brain of rats after hippocampal injury inflicted by kainic acid.

机译:黄酮酸造成的海马损伤后大鼠大鼠脑中的线粒体脱蛋白UCP2的表达。

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摘要

The expression of mitochondrial protein UCP2 and cytochrome C-oxidase subunit III genes in the hippocampus and prefrontal cortex was evaluated by real-time PCR 3 and 7 days after microinjection of kainic acid into the dorsal hippocampus. In contrast to cytochrome C-oxidase subunit III mRNA, the level of UCP2 mRNA in the hippocampus increased 1 week after microinjection of kainic acid. The expression of both genes in the prefrontal cortex did not differ from the control. Presumably, activation of UCP2 synthesis in hippocampal injury indicates the neuroprotective effects of this protein.
机译:通过实时PCR 3和7天在Kinainic酸进入背部海马的微量注射后,通过实时PCR 3和7天进行线粒体蛋白质UCP2和细胞色素C-氧化酶亚基III基因的表达。 与细胞色素C-氧化酶亚基III mRNA相比,海马UCP2 mRNA的水平增加1周后Kinain acid酸微调后1周。 前额叶皮层中两种基因的表达与对照没有不同的不同。 据推测,海马损伤中的UCP2合成的激活表明该蛋白质的神经保护作用。

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