Metabolic Effects of Mixture Containing Branched-Chain Amino Acids and Taurine during Subchronic Poisoning with Barbiturates.

摘要

We studied the effect of a mixture containing branched-chain amino acids and taurine on the pool of free amino acids and their derivatives during chronic phenobarbital poisoning. Subchronic barbiturate poisoning produced by daily intraperitoneal injection of phenobarbital caused imbalance in the content of some amino acids in blood plasma and liver of rats. Treatment with the mixture of branched-chain amino acids and taurine normalized the content of amino acids in the liver and blood plasma of animals with subchronic phenobarbital poisoning. The mixture of branched-chain amino acids and taurine corrects metabolic processes and normalized the peripheral pool of amino acids. Our findings extend the range for application of amino acids in clinical practice.