Morphological and functional state of rat ovaries in early and late periods after administration of platinum cytostatics.

Borovskaya TG; Goldberg VE; Fomina TI; Pakhomova AV; Kseneva SI; Poluektova ME; Goldberg ED

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Morphological and functional state of rat ovaries in early and late periods after administration of platinum cytostatics.

机译：铂细胞抑制学施用后早期和晚期大鼠卵巢的形态学和功能状态。

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Experiments on Wistar rats showed that cisplatin and carboplatin induced similar morphological alterations in the ovaries. Both agents reduced the number of structural and functional elements, but the effect of cisplatin was more pronounced. Morphological changes observed in the early period after injection of the preparations were accompanied by prolongation of the estrous cycle, which was longer in rats treated with carboplatin. Partial and reversible sterility was observed in females at the early terms after cisplatin treatment.

机译：Wistar大鼠的实验表明，顺铂和卡铂在卵巢中诱导相似的形态改变。两种试剂减少了结构和功能元素的数量，但顺铂的效果更加明显。在注射制剂后观察到的形态变化伴随着腐烂的循环延长，在用卡铂处理的大鼠中延长。在顺铂治疗后，在雌性中观察到部分和可逆性无菌。

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《Bulletin of experimental biology and medicine》 |2004年第4期|共5页
作者
Borovskaya TG; Goldberg VE; Fomina TI; Pakhomova AV; Kseneva SI; Poluektova ME; Goldberg ED;
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作者单位

Institute of Pharmacology Tomsk Research Center Siberian Division of the Russian Academy of Medical Sciences.;

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正文语种 rus
中图分类基础医学;
关键词
Ovary; Cisplatin; Carboplatin; Platinum; Partial; 卵巢; 顺铂; 卡铂; 铂;

机译：Ovary;Cisplatin;Carboplatin;Platinum;Partial;卵巢;顺铂;卡铂;铂;

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1. Morphological and functional state of rat ovaries in early and late periods after administration of platinum cytostatics. [J] . Borovskaya TG, Goldberg VE, Fomina TI, Bulletin of experimental biology and medicine . 2004,第4期

机译：给予铂类细胞抑制剂后早期和晚期大鼠卵巢的形态和功能状态。
2. Morphological and functional state of rat ovaries in the early and late periods after injection of vepesid. [J] . Borovskaya TG, Goldberg VE, Pakhomova AV, Bulletin of experimental biology and medicine . 2006,第5期

机译：注射vepesid后早期和晚期大鼠卵巢的形态和功能状态。
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7. : "This paper deals with the functionality of the flaked stone assemblages from several Neolithic sites of the NE of the Iberian Peninsula. The chronological framework ranges from the mid-6th to the mid-4th millennium cal. BCE, which corresponds to the Early and Middle Neolithic. This long period ranges from the arrival of the first farming communities in the Iberian Peninsula, around 5600-5500 cal. BCE, to 3600-3500 cal. BCE, two millennia later, when Neolithic communities had stably occupied most of the available territory, from the mountainous areas of the Pyrenees to the coastal areas of the Mediterranean.In this context, the NE of the Iberian Peninsula is one of the areas where a major number of use-wear analyses have been carried out, especially for what concerns the Neolithic period. This is mainly due to the interest shown by the directors of the excavations and by the Spanish use-wear specialists as well; both participated and cooperated in order to enlarge the number of contexts studied, making the NE of the Iberian Peninsula one of the areas of Europe with the largest number of ‘functional studies’. As a result, today we have a reliable picture of the type of lithic tools used by the first farming groups, how they were used, and which needs they were satisfying.The methodology employed for this type of analysis is today broadly shared by most use-wear specialists. A stereoscopic microscope is used together with a reflected-light microscope for the analysis of the archaeological specimens. Afterwards, the observed use-wear traces are compared with the traces from experimental tools. This study primarily made use of the tools preserved at the ‘Traceoteque’ of the Institución Milà y Fontanals of the CSIC of Barcelona.This paper presents the results obtained for the different types of analysed sites and the relative lithic assemblages. In this way, tools from different contexts are compared: open-air sites, caves and rock-shelters, pit-sites, burials, and mining sites. Such a diversity of contexts allowed for the exploration of the existence of recurrences and differences in the functionality of the lithic tools from one site to another. The results obtained have also provided information on some aspects related to the economic processes carried out at the different sites, caves, rock-shelters and open-air contexts. It has been possible to gain fresh data on the types of tasks carried out and their relative importance for each site, their relation with the geographical and environmental context and the natural resources available there. In addition, analysing tools recovered from burials – mainly individual inhumations – provided information on the relationships between the buried individuals and the working tools, in particular exploring the relationships between sex and age patterns and the types of tools deposited as goods.In conclusion, use-wear analysis allowed for the exploration of a variety of issues; from technical aspects related to the production and management of the lithic resources to social aspects related to the subsistence activities and the individuals that carried them out." [O] . Gibaja Bao, Juan Francisco, Mazzucco, Niccolo 2015

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机译：神经毒性的生化，功能和形态学指标：急性给予三甲基锡对发育中大鼠的影响

Morphological and functional state of rat ovaries in early and late periods after administration of platinum cytostatics.

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