Mechanisms of Psychopharmacological Effects of Alkaloid Z77 Under Conditions of Brain Ischemia

摘要

We studied the psychopharmacological effects of atisine-type diterpene alkaloid Z77 in a rat model of brain ischemia in the morning and at night. The type of developing locomotor disorders in animals was shown to depend on circadian rhythms. Administration of Z77 substantially corrected manifestations of psychoneurological symptoms. The parameters of orientation and exploratory behavior and conditioned refl ex activity were normalized. The key role of receptors of neural stem cells to fi broblast growth factor in the realization of their growth potential under the infl uence of the alkaloid was demonstrated. Under in vitro conditions, antibodies to fi broblast growth factor receptor abolished the increase in the number of neural CFU caused by Z77 in the culture of intact cells from the paraventricular region of the brain.