Effect of Local Application of Superoxide Dismutase on Dielectric Parameters of Cooled Skin in Rats

摘要

The effect of on Changes in dielectric parameters of the skin (modulus of complex dielectric permittivity |epsilon| and dielectric loss tangent tgdelta) were studied on rats with local surface contact cooling followed by treatment with various cream formulations. Addition of antioxidant superoxide dismutase (SOD) to the cream significantly prevented the shifts in these parameters, which attested to less pronounced changes in the water balance in SOD-treated skin. Application of SOD during the early terms after cooling accelerated wound healing. Histological examination performed on posttraumatic day 60 revealed better integrity of the skin structures (hair follicle, sweat and sebaceous gland), which indicates ability of SOD to prevent and ameliorate the degree of cold-induced damage in the skin.