FBXW7 is a biologically validated cancer driver gene for CLL

摘要

F-box and WD40 repeat domain containing-7 (FBXW7) is one of the statistically defined candidate cancer driver genes for chronic lymphocytic leukemia (CLL). In this issue of Blood, Close et al describe functional genomic experiments that have verified the biological consequences of mutations in FBXW7, which can now be considered a validated driver gene for CLL.(1)