Low FV beneficial in FVFVIII deficiency?

摘要

In this issue of Blood, Shao and colleagues demonstrate that the low factor V (FV) levels in patients with combined deficiency of FV and FVIII (F5F8D) may in fact be beneficial for the patients and ameliorate their bleeding tendency.(1) This report adds to the growing list of observations that FV not only is procoagulant but also that it works as an anticoagulant. The paper brings new understanding of the basic pathology of F5F8D and also lays the foundation for a change in the treatment strategy of the disease.