Tearing ATL apart to find HTLV's sinister plans

摘要

In this issue of Blood, Wong et al report that interferon regulatory factor 4 (IRF4) and nuclear factor kappa light chain enhancer of activated B cells (NF-kappa B) drive maintenance of adult T-cell leukemia/lymphoma (ATL) by coordinately stimulating a transcriptional regulatory network normally intended for promoting T-cell immune functions.(1)