Huntingdon's disease (HD) is described as a progressive, inherited, neurodegenerative disorder characterised by movement abnormalities, cognitive impairments and an emotional disturbance (Bates et al., 2002). The genetic mutation for HD has been localised to the HD gene located on chromosome 4p 16.3, which contains a polymorphic, unstable GAG repeat (HD Collaborative Research Group, 1993). The age of onset of the disease can vary between childhood and old age depending on the size of the mutation (number of GAG repeats).
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机译：亨廷顿病（HD）被描述为一种以运动异常，认知障碍和情绪障碍为特征的进行性遗传性神经退行性疾病（Bates等，2002）。 HD的遗传突变已定位于位于染色体4p 16.3上的HD基因，该基因含有多态的，不稳定的GAG重复序列（HD Collaborative Research Group，1993）。根据突变的大小（GAG重复次数），疾病的发病年龄可能在儿童和老年之间有所不同。
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