The activity of lysosomal enzymes in blood serum, liver, kidney and skeletal muscle of rabbits divergently selected for locomotor activity in open-field test

摘要

Twenty males were used from generation 8 of rabbits divergently selected for high (line H, n=10) vs. low (line L, n=10) locomotor activity in the open-field (OF-test). At the age of 98 days, blood samples were withdrawn from the ear vein and the rabbits were killed. Immediately, liver, kidney and the left femoral muscle samples were excised. In lysosomal fractions of blood serum and three tissues mentioned the activity of lysosomal enzymes AlaAP, LeuAP, ArgAP, Cat D and L, AcP, EL, LAL, BGRD, BGAL, BGLU, aGlu, MAN and HEX was determined. Significant interline differences were identified in activity of blood and tissue enzymes in question. The results suggest that the divergent selection for high vs. low locomotor activity in the open-field (OF-test)alters the lysosomal degradation processes in the organism.