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首页> 外文期刊>Bioorganic and medicinal chemistry >Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities
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Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

机译：合成苯并多环笼胺：NMDA受体拮抗剂，胰蛋白酶和抗病毒活性

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摘要

The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11- dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein.
机译：报道了几种6,7,8,9,10,11-11-六羟基-9-甲基-5,7：9,11-二甲醇-5H-苯并羰基-7-胺的合成。 其中几个显示出低微摩尔NMDA受体拮抗剂和/或胰蛋白酶活性。 两种化合物赋予微摩尔抗囊泡口炎病毒活性，而只有一种化合物显示微摩尔抗流感活性。 该化合物的抗流感活性似乎不能通过阻断M2蛋白来介导。

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  • 作者

    TorresE.; DuqueM.D.; López-QuerolM.; TaylorM.C.; NaesensL.; MaC.; PintoL.H.; SuredaF.X.; KellyJ.M.; VázquezS.;

  • 作者单位

    Laboratori de Química Farmacutica Facultat de Farmcia and Institute of Biomedicine (IBUB);

    Laboratori de Química Farmacutica Facultat de Farmcia and Institute of Biomedicine (IBUB);

    Unitat de Farmacologia Facultat de Medicina i Cincies de la Salut Universitat Rovira i Virgili C;

    London School of Hygiene and Tropical Medicine Department of Infectious and Tropical Diseases;

    Rega Institute for Medical Research Katolieke Universiteit Leuven 3000 Leuven Belgium;

    Department of Neurobiology and Physiology Northwestern University Evanston IL 60208-3500 United;

    Department of Neurobiology and Physiology Northwestern University Evanston IL 60208-3500 United;

    Unitat de Farmacologia Facultat de Medicina i Cincies de la Salut Universitat Rovira i Virgili C;

    London School of Hygiene and Tropical Medicine Department of Infectious and Tropical Diseases;

    Laboratori de Química Farmacutica Facultat de Farmcia and Institute of Biomedicine (IBUB);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学 ;
  • 关键词

    Amantadine; Antivirals; Cage compounds; NMDA; Trypanosoma;

    机译：Amantadine;抗病毒;笼子化合物;NMDA;锥虫瘤;

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