In this prospective study, we investigated the effects of anxiety on the induction dose of propofol and subsequent cardiovascular changes in 197 patients. Pre-operative state and trait anxiety scores were measured using the State Trait Anxiety Inventory. Propofol was administered at 40 mg x kg(-1) x h(-1). Propofol dose was recorded at loss of verbal response and when EEG Bispectral Index decreased to 50. Thereafter, propofol infusion rate was reduced to 8 mg x kg(-1) x h(-1). Cardiovascular data were collected for 15 min after starting induction. Maximum percentage decreases in heart rate and mean arterial pressure, and the point at which the latter occurred, were recorded. On multivariate analysis, anxiety scores did not significantly affect propofol dose or cardiovascular end-points, although Bispectral Index at loss of verbal response decreased with increasing trait anxiety (p = 0.02). Anxiety, measured using State Trait Anxiety Inventory, does not appear independently to affect the induction characteristics of propofol.
展开▼
机译：在这项前瞻性研究中，我们调查了197位患者焦虑对丙泊酚诱导剂量和随后心血管变化的影响。使用状态特质焦虑量表测量术前状态和特质焦虑评分。异丙酚的剂量为40 mg x kg（-1）x h（-1）。记录异丙酚的剂量是在失去言语反应时以及脑电双光谱指数降至50时。此后，异丙酚的输注速度降至8 mg x kg（-1）x h（-1）。开始诱导后15分钟收集心血管数据。记录最大百分比的心率和平均动脉压下降以及后者发生的时间点。在多变量分析中，尽管在言语反应丧失时的双谱指数随性状焦虑的增加而降低，但焦虑评分并未显着影响异丙酚的剂量或心血管终点（p = 0.02）。使用状态特质焦虑量表测量的焦虑不会独立出现，从而影响异丙酚的诱导特性。
展开▼
