Muscle relaxants--pancuronium and vecuronium.

摘要

By 1960 muscle relaxants were well established in anaesthesia. Tubocurarine was the drug of choice for operations of any significant duration, but because tubocurarine lasted around thirty minutes, gallamine was often preferred for shorter operations. This was despite gallamine causing tachycardia and a growing belief that it led to increased wound bleeding. Diallyl nor-toxiferine (alcuroni-um, Alloferin) was introduced by Hugin and Kissling in 1961. It was twice as potent as tubocurarine, caused less hypotension on induction and was soon widely accepted. However, it was not a dramatic departure from the available drugs.