Corticospinal tract degeneration and possible pathogenesis in ALS evaluated by MR diffusion tensor imaging

摘要

BACKGROUND: MR diffusion tensor imaging (DTI) appears to be a powerful method to investigate the neuronal and axonal fibre distribution in the human brain. Changes in diffusion characteristics of water molecules in the white matter can be estimated as the apparent diffusion coefficient ( ADC) and the fractional anisotropy index ( FA).