SYNTHESIS, CRYSTAL STRUCTURE, AND ANTICANCER ACTIVITY OF A In(III) COORDINATION POLYMER BASED ON A FLEXIBLE 5-(4-CARBOXYBENZYL)ISOPHTHALIC ACID LIGAND

摘要

In this study, a new In(III)-based coordination polymer [In(cpt)](DMF)(H2O) (1, DMF = = N,N-dimethylformamide) is prepared using a newly designed ligand 5-(4-carboxybenzyl)iso-phthalic acid (H3cpt). Complex 1 is characterized by single crystal and powder X-ray diffraction and the thermogravimetric analysis. The structure of 1 involves one-dimensional chainlike units containing In(III), further combined with cpt3- ligands to obtain a 3D framework structure. The ultrasonic treatment method is used to produce nanoparticles of 1 (nano 1). MTT assay was carried out to explore the cytotoxicity of nano 1 on HMEC-1 hemangioendothelioma cells, and RT-PCR was utilized to assess activation of the PTEN/PI3K/Akt pathway.