Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit in Pichia pastoris

Wang Baolong; Wang Xin; Wayne Chris; Wang Xiangxiang; Han Lei; Ye Li; Zhao Qun; Jiang Guixiang; Feng Meiqing

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Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit in Pichia pastoris

机译：通过与巴斯德毕赤酵母中人绒毛膜促性腺激素β亚基的两个羧基末端肽片段融合来生产治疗性蛋白质

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Objective To produce a therapeutic protein (endostatin) by fusion with two fragments of the carboxyl-terminal peptide (CTP) of the human chorionic gonadotropin beta-subunit in Pichia pastoris.

机译：目的通过与巴斯德毕赤酵母中人绒毛膜促性腺激素β亚基的羧基末端肽（CTP）的两个片段融合来生产治疗蛋白（内皮抑素）。

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《Biotechnology Letters》 |2016年第5期|共7页
作者
Wang Baolong; Wang Xin; Wayne Chris; Wang Xiangxiang; Han Lei; Ye Li; Zhao Qun; Jiang Guixiang; Feng Meiqing;
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正文语种 eng
中图分类分子生物学;
关键词
Cancer angiogenesis; Carboxyl-terminal peptide; Endostatin; Endothelial cells; Pichia pastoris;

机译：肿瘤血管生成;羧基末端肽;内皮抑素;内皮细胞;巴斯德毕赤酵母;

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1. Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit in Pichia pastoris [J] . Wang Baolong, Wang Xin, Wayne Chris, Biotechnology Letters . 2016,第5期

机译：通过与巴斯德毕赤酵母中人绒毛膜促性腺激素β亚基的两个羧基末端肽片段融合来生产治疗性蛋白质
2. Processing of O-linked Glycosylation in the Chimera Consisting of alpha-Subunit and Carboxyl-terminal Peptide of the Human Chorionic Gonadotropin beta-Subunit is Affected by Dimer Formation with Follicle-stimulating Hormone beta-Subunit. [J] . Furuhashi M, Suganuma N Endocrine journal . 2004,第1期

机译：人绒毛膜促性腺激素β-亚基的α-亚基和羧基末端肽组成的嵌合体中的O-联糖基化处理受卵泡刺激激素β-亚基的二聚体形成影响。
3. Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin β Subunit to the N-Terminal and C-Terminal Coding Sequence [J] . Fuad Fares, Avri Havron, Eyal Fima International Journal of Cell Biology . 2011,第2期

机译：通过将人类绒毛膜促性腺激素β亚基的三个羧基末端肽与N末端和C末端编码序列融合，设计长效促红细胞生成素
4. Site-specific characterization of N-/O-glycosylation on therapeutic human chorionic gonadotropins using online LC/MS and Tandem Mass Tags [C] . Hongbin Zhu, Chen Qiu, Ashley C. Ruth, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用在线LC / MS和串联质量标签的治疗性人绒毛膜促性腺激素的N- / O-糖基化的特异性特异性
5. Optimizing production methods for artificial silk proteins through bioreactor and purification studies of recombinant proteins expressed from Pichia pastoris [D] . Ramey, Aaron Thomson 2006

机译：通过生物反应器优化人工丝蛋白的生产方法并纯化巴斯德毕赤酵母表达的重组蛋白
6. Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin β Subunit to the N-Terminal and C-Terminal Coding Sequence [O] . Fuad Fares, Avri Havron, Eyal Fima 2011

机译：通过将人类绒毛膜促性腺激素β亚基的三个羧基末端肽与N末端和C末端编码序列融合设计长效促红细胞生成素
7. Designing a Long-Acting Human Growth Hormone (hGH) by Fusing the Carboxyl-Terminal Peptide of Human Chorionic Gonadotropin β-Subunit to the Coding Sequence of hGH [O] . Fuad Fares, Rachel Guy, Ahuva Bar-Ilan, 2010

机译：通过融合人绒毛膜促性腺激素β-亚基的羧基 - 末端肽至HGH的编码序列来设计长效人体生长激素（HGH）

Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin beta-subunit in Pichia pastoris

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