首页> 外文期刊>Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences >Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis)
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Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis)

机译:五味子,脱氧五味子和五味子B在大鼠中药和五味子合用后的比较药代动力学和组织分布

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摘要

Recently, combination therapy with acupuncture and medicine as a practical strategy to treat diseases has gained increasing attention. The present study aimed to investigate whether acupuncture stimulation at ST.36 had a potential impact on the pharmacokinetics and tissue distribution of lignans. An HPLC-ESI/MS analytical method was established and successfully applied to a comparative study of drug concentration in plasma and tissues of three lignans. The parameters area under the plasma concentration-time curve from time zero to the final measurable point and from time zero to infinity, and peak concentration were significantly increased, with a prolonged mean residence time and a corresponding decrease in clearance in comparision with the Schisandra-alone group. Additionally, tissue concentrations of three lignans were improved in the group with acupuncture, especially in liver. The results indicated that acupuncture has a synergistic effect on the pharmacokinetics and tissue distribution of the three lignans, which could postpone their elimination, resulting in a longer blood circulating time in rat plasma and prolonged residence time in target tissues, leading to higher tissue concentration. The findings provide some scientific evidence for the mechanism of the combined use of acupuncture and herbal medicine. Furthermore, we suggest that acupuncture and its combination with herbal medicine should be investigated further as a possible adjuvant therapy in clinical treatment for liver injury. Copyright (C) 2014 John Wiley & Sons, Ltd.
机译:近年来,以针灸和药物相结合作为治疗疾病的实用策略越来越受到关注。本研究旨在调查针刺在ST.36上是否对木脂素的药代动力学和组织分布有潜在影响。建立了HPLC-ESI / MS分析方法,并将其成功地用于三种木脂素血浆和组织中药物浓度的比较研究。与五味子相比,从零时间到最终可测量点以及从零时间到无穷大的血浆浓度-时间曲线下的参数面积和峰浓度显着增加,平均停留时间延长,清除率相应降低。单独组。此外,针刺组(尤其是肝脏)的三种木脂素的组织浓度得到改善。结果表明,针刺对三种木脂素的药代动力学和组织分布具有协同作用,可以延缓它们的消除,从而导致大鼠血浆中血液循环时间延长,在靶组织中的停留时间延长,从而导致组织浓度升高。这些发现为针灸和草药联合使用的机理提供了一些科学依据。此外,我们建议应进一步研究针灸及其与草药的结合,作为临床治疗肝损伤的可能辅助疗法。版权所有(C)2014 John Wiley&Sons,Ltd.

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