Antihypoxant activity and mechanisms of action of some natural and synthetic compounds

摘要

The role of hypoxia as one of the main factors in the development of various pathologic processes is discussed. The anthihypoxic efficacy and mechanisms action of synthetic drugs (oliphen, amtizole, mexidol) and some polyphenolic agents of plant origin are considered. Among the mechanisms of antihypoxant action of these drugs, an especially important role belongs to the stimulation of expression of heat shock proteins and hypoxia-induced factors, which increase the stability of organism under the conditions of oxygen insufficiency.