Effect of potassium bromate on liver and blood constituents of Wistar albino rats.

摘要

24 Wistar albino rats were divided into 4 groups and treated orally with potassium bromate at doses of 0, 50, 100 and 200 mg/kg body weight (b.wt.) for 21 days. The rats that received 200 mg/kg b.wt. died within 18 days. A significant reduction in haemoglobin, packed cell volume and mean cell haemoglobin concentration values were observed in animals that received 200 mg/kg b.wt. of potassium bromate in the second week, while no changes occurred in the groups given 50 and 100 mg/kg b.wt. The activity of alanine transaminase [alanine aminotransferase] was significantly increased in rats that received 100 and 200 mg/kg b.wt. from the first week, while total protein and albumin were significantly decreased from the first week in animals given 200 mg/kg b.wt. and the second week at the dose of 100 mg/kg b.wt. Histologically, liver degeneration and haemorrhage were evident in rats given 100 and 200 mg/kg b.wt. The potassium bromate dose of 50 mg/kg b.wt. did not cause any changes compared to the control.