THE EFFICACY OF RIVAROXABAN IN REDUCING THE RISK OF CARDIOVASCULAR EVENTS IN PATIENTS WITH STABLE ISCHEMIC HEART DISEASE AND PERIPHERAL DISEASE. RESULTS OF THE COMPASS TRIAL

摘要

The article considers modern approaches to the secondary prevention of cardiovascular events in patients with stable ischemic heart disease (IHD) and/or atherosclerosis of peripheral arteries (peripheral artery disease - PAD) with the oral anticoagulant rivaroxaban. The results of the first international prospective phase III study COMPASS for the evaluation of efficacy and safety of rivaroxaban including 27395 patients with stable IHD or PAD, are discussed. The results of the study were presented at European Congress of Cardiology 2017. Rivaroxaban reduced of the risk of cardiovascular death, stroke and myocardial infarction by 24%. The results of the study confirm the positive balance of risk/benefit and supplement the previously obtained data on the efficacy of rivaroxaban in patients with cardiovascular diseases.