Potential of bone marrow mesenchymal stem cells for the treatment of diseases associated with damage of cardiac tissue.

摘要

Ability of mononuclear and adhesive cells to form differentiated elements of various tissues and organs in tissue culture in vitro has been studied in experiments on CBA mice. It has been established that adhesing mesenchymal stem cells are present in bone marrow. These cells are able to generate muscular, nervous, endothelioid, epithelioid, reticular, fibroblastoid, chondrogenic, osteogenic, and other types of cells. Mesenchymal islets have been frequently found both as parts of colonies and as independent units. Potential developmental flexibility of mesenchymal cells allows to suppose their high efficacy in pathogenetic cell therapy of heart diseases when besides damaged muscular elements vascular and nervous elements should be also restored. Mononuclear cells have not demonstrated this ability. They formed mainly monocyte-macrophagal and lymphoid cells.