Cooperative study 'posthospital rehabilitation of patients with coronary heart disease after acute coronary incidents' conducted in moscow region.

摘要

Effect of physical training, therapy with extended-release nicotinic acid (enduracin) or their combination on clinical course of the disease, physical working capacity, hemodynamics and blood lipids was studied in 136 patients. Patients were recruited 8-12 weeks after onset of acute coronary incident in several hospitals of Moscow region and followed up for 1 year. Type of intervention implemented in a given hospital was determined by randomization of the hospitals. Combined use of training and nicotinic acid resulted in increased physical working capacity, improved hemodynamics both at rest and during exercise, improved systolodiastolic left ventricular function and lipid profile. Combined use of interventions produced better effect than each one alone. However positive significant effect of enduracin on physical working capacity, blood pressure and frequency of angina was also demonstrated. The data obtained were used for creation of recommendations on out of hospital physical rehabilitation of this group of patients.